Which of the following statements about PPIs is accurate?

The statement regarding the link between proton pump inhibitors (PPIs) and osteoporosis with long-term use is accurate. Research has indicated that prolonged use of PPIs can lead to a decreased absorption of calcium, which is crucial for bone health. This decrease in calcium absorption may increase the risk of bone fractures and contribute to osteoporosis, especially in patients who are already at risk due to factors like age or other medications.

This concern stems from the mechanism of action of PPIs, which reduce gastric acid secretion. Adequate gastric acid is necessary for the effective absorption of certain nutrients, including calcium. As a result, patients who take PPIs over extended periods may experience an increased risk of skeletal complications.

Understanding this connection is vital when prescribing or recommending PPIs, as healthcare professionals must weigh the benefits of acid suppression against potential long-term effects on bone density and overall health.