What symptom might indicate a worsening of a patient’s condition with NSAID-induced ulcers?

The presence of blood in the stool is a significant indicator that a patient's condition related to NSAID-induced ulcers may be worsening. NSAIDs, or non-steroidal anti-inflammatory drugs, can lead to the development of ulcers in the gastrointestinal tract by disrupting the protective mucosal barrier and increasing acid secretion. When an ulcer is active, it can result in gastrointestinal bleeding, which may manifest as blood in the stool, either as bright red blood or as dark, tarry stools, depending on the location and severity of the bleeding.

Recognizing blood in the stool as a symptom is critical, as it suggests that the ulceration may have progressed to a point where it is causing serious complications, such as hemorrhage. Prompt medical evaluation and intervention would be necessary to address these potential risks, highlighting the importance of monitoring patients on NSAIDs for such signs of gastrointestinal distress.