What substance is NOT typically associated with elevated creatinine levels?

Elevated creatinine levels are often an indicator of impaired kidney function or damage, as creatinine is a waste product that the kidneys normally filter out of the blood. Substances that can affect kidney function often lead to increased levels of creatinine.

Calcium supplements are not generally linked to elevated creatinine levels. While excessive calcium intake can impact kidney function in certain specific scenarios, routine use of calcium supplements in normal dietary amounts typically does not have a direct effect on creatinine levels. In fact, they are often used safely in the management of bone health and do not impair kidney function in healthy individuals.

On the other hand, NSAIDs, metformin, and aminoglycosides are all associated with elevated creatinine levels due to their potential nephrotoxic effects or their impact on renal clearance. NSAIDs can reduce blood flow to the kidneys, leading to an increase in creatinine. Metformin can cause lactic acidosis in patients with renal impairment, which can also result in elevated creatinine. Aminoglycosides, being a class of antibiotics, can cause acute kidney injury, thus raising creatinine levels as well.

Understanding the role of these substances in renal function highlights why calcium supplements stand out as not typically correlating with increased creat