What might prolonged NSAID use lead to?

Prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) is particularly associated with the development of peptic ulcer disease. NSAIDs work by inhibiting the production of certain prostaglandins that protect the gastric mucosa, which can lead to increased gastric acid secretion and decreased mucosal defense. This impaired protection makes the gastrointestinal tract more susceptible to ulceration.

When NSAIDs are used over extended periods, the risk of both gastric and duodenal ulcers increases significantly. Symptoms of peptic ulcer disease can include abdominal pain, bloating, indigestion, and complications can arise such as bleeding or perforation.

On the other hand, while prolonged NSAID use can have other health implications, such as potential effects on blood pressure or renal function, these are not as directly linked to the drug as the risk of peptic ulcer disease. Gallbladder disease and liver failure are less commonly associated with NSAID use compared to gastrointestinal complications.