What is the class of medication considered the gold standard in the treatment of GERD?

Proton Pump Inhibitors (PPIs) are regarded as the gold standard in the treatment of gastroesophageal reflux disease (GERD) because they effectively suppress gastric acid secretion at the source. By inhibiting the proton pumps in the stomach lining responsible for producing acid, PPIs significantly reduce both the volume and the acidity of gastric secretions. This leads to improved healing of the esophagus, reduction in GERD symptoms, and a lower risk of complications associated with chronic acid exposure, such as esophagitis.

For many patients, PPIs provide rapid symptom relief and long-term management, making them highly effective therapies compared to other classes of medications. While H2 blockers and antacids can also be used in the management of GERD, they are generally not as effective as PPIs for chronic treatment. Dietary supplements do not hold a standard or proven role in the management of GERD symptoms or esophageal healing, making them less relevant in this context.