What is a common manifestation of acute graft rejection after a liver transplant?

Acute graft rejection after a liver transplant often presents with systemic symptoms that indicate the body is mounting an immune response against the transplanted organ. Fever is a classic sign of acute rejection and serves as an indicator of inflammation or infection. During this phase, the patient's immune system recognizes the transplanted liver as foreign and initiates an immune response, which can lead to heightened body temperature as part of the inflammatory process.

Other manifestations can include jaundice, elevated liver enzymes, and changes in liver function tests, but fever stands out as a key initial systemic symptom. This is why selecting fever as the manifestation of acute graft rejection is well-founded in clinical practice. It signals not only possible rejection but may also warrant further investigation to differentiate from other potential complications such as infection.